The efficacy of a synbiotic containing Bacillus Coagulans in treatment of irritable bowel syndrome: a randomized placebo-controlled trial.

ABSTRACT:

Aim

We aimed to evaluate the efficacy of a synbiotic containing Bacillus Coagulans in treatment of IBS.

Background

Some studies have shown the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS).

Patients and methods

Adult IBS patients (n=85) were randomized to receive a synbiotic containing Bacillus Coagulans or placebo for 12 weeks. Frequency of IBS symptoms including abdominal pain (scored 1 to 7), and diarrhea and constipation (scored 1 to 5) was evaluated before and after the intervention and then after nine months follow-up.

Results

Twenty-three patients in the synbiotic group and 33 patients in the placebo group completed the study (age = 39.8±12.7 years, 78.6% female). After treatment, more reduction in abdominal pain frequency was

SUBMITTER: Rogha M 

PROVIDER: S-EPMC4129566 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature