Ontology highlight
ABSTRACT:
SUBMITTER: Zheng S
PROVIDER: S-EPMC4129656 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Molecular cell 20130926 1
The mechanisms that underlie and dictate the different biological outcomes of E2F-1 activity have yet to be elucidated. We describe the residue-specific methylation of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetric dimethylating PRMT5 and relate the marks to different functional consequences of E2F-1 activity. Methylation by PRMT1 hinders methylation by PRMT5, which augments E2F-1-dependent apoptosis, whereas PRMT5-dependent methylation favors pr ...[more]