TRAF6 polymorphisms not associated with the susceptibility to and severity of sepsis in a Chinese population.

ABSTRACT:

Background

The tumor necrosis factor recepter associated factor (TRAF) 6 is an important intracellular adapter protein that plays a pivotal role in activating multiple inflammatory and immune related processes induced by cytokines. TRAF6 represents a strong candidate susceptibility factor for sepsis. We investigated whether polymorphisms at the TRAF6 gene are associated with the susceptibility to and severity of sepsis.

Methods

A hospital-based case-control study was conducted with 255 patients with sepsis and 260 controls who were recruited from Zhengzhou, China. Haplotype tagging single nucleotide polymorphisms (htSNPs) were selected from the HapMap database and genotyped using the SNPstream genotyping platform. The associations with the susceptibility and disease severity

SUBMITTER: Fang Y 

PROVIDER: S-EPMC4129682 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature