Association of ALOX5AP with ischemic stroke in eastern Chinese.

ABSTRACT:

Background

5-lipoxygenase protein (ALOX5AP) has been recognized as a susceptibility gene for stroke and coronary artery diseases. The present study was to explore the role of this gene in the eastern Chinese patients with ischemic stroke.

Methods

Using a case-control design, we studied 658 patients with ischemic stroke and 704 unrelated population-based controls who were age- and sex-matched. The 658 patients were classified by the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Two single-nucleotide polymorphisms (SNPs) covering ALOX5AP were genotyped.

Results

The genotype frequencies of TG of the SNPs rs17222919 located in the promoter of the ALOX5AP gene were significantly higher in patients with ischemic stroke than in controls (OR (*)=1.34, 95%CI(*)=1.02-1.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4129791 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature