Early viral kinetics during hepatitis C virus genotype 6 treatment according to IL28B polymorphisms.

ABSTRACT:

Aim

To investigate the early viral kinetics and interleukin-28B (IL28B) polymorphisms of hepatitis C genotype 6 during pegylated interferon and ribavirin therapy.

Methods

Sixty-five patients with chronic hepatitis C virus (HCV) infection treated with pegylated interferon and ribavirin (PEG-IFN/RBV) were included, of whom 15 (23.1%), 16 (24.6%) and 34 (52.3%) patients were infected with hepatitis C genotype 1 (HCV-1), genotype 3 (HCV-3) and genotype 6 (HCV-6), respectively. Serum HCV-RNA levels were measured frequently during the first 4-wk of therapy. DNA extracted from samples was analyzed for the IL28B single nucleotide polymorphism (SNP) rs12979860 by polymerase chain reaction and direct sequencing.

Results

During the first 4-wk of therapy, the mean viral decline f

SUBMITTER: Akkarathamrongsin S 

PROVIDER: S-EPMC4130872 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature