Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety.

ABSTRACT:

Objective

To determine the effectiveness and safety of perioperative tranexamic acid use in patients undergoing total hip or knee arthroplasty in the United States.

Design

Retrospective cohort study; multilevel multivariable logistic regression models measured the association between tranexamic acid use in the perioperative period and outcomes.

Setting

510 US hospitals from the claims based Premier Perspective database for 2006-12.

Participants

872,416 patients who had total hip or knee arthroplasty.

Intervention

Perioperative intravenous tranexamic acid use by dose categories (none, ≤ 1000 mg, 2000 mg, and ≥ 3000 mg).

Main outcome measures

Allogeneic or autologous transfusion, thromboembolic complications (pulmonary embolism, deep venous thrombos

SUBMITTER: Poeran J 

PROVIDER: S-EPMC4130961 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature