Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport.

ABSTRACT: In animal cells, microtubule and actin tracks and their associated motors (dynein, kinesin, and myosin) are thought to regulate long- and short-range transport, respectively. Consistent with this, microtubules extend from the perinuclear centrosome to the plasma membrane and allow bidirectional cargo transport over long distances (>1 μm). In contrast, actin often comprises a complex network of short randomly oriented filaments, suggesting that myosin motors move cargo short distances. These observations underpin the "highways and local roads" model for transport along microtubule and actin tracks. The "cooperative capture" model exemplifies this view and suggests that melanosome distribution in melanocyte dendrites is maintained by long-range transport on microtubules followed by actin/myo

SUBMITTER: Evans RD 

PROVIDER: S-EPMC4131108 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature