Chronic stress, depressive symptoms, anger, hostility, and risk of stroke and transient ischemic attack in the multi-ethnic study of atherosclerosis.

ABSTRACT:

Background and purpose

This study investigated chronic stress, depressive symptoms, anger, and hostility in relation to incident stroke and transient ischemic attacks in middle-aged and older adults.

Methods

Data were from the Multi-Ethnic Study of Atherosclerosis (MESA), a population-based cohort study of 6749 adults, aged 45 to 84 years and free of clinical cardiovascular disease at baseline, conducted at 6 US sites. Chronic stress, depressive symptoms, trait anger, and hostility were assessed with standard questionnaires. The primary outcome was clinically adjudicated incident stroke or transient ischemic attacks during a median follow-up of 8.5 years.

Results

One hundred ninety-five incident events (147 strokes; 48 transient ischemic attacks) occurred during follo

SUBMITTER: Everson-Rose SA 

PROVIDER: S-EPMC4131200 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature