Mitochondrial pathobiology in ALS.
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ABSTRACT:
SUBMITTER: Martin LJ
PROVIDER: S-EPMC4131252 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
Mitochondrial pathobiology in ALS.
Journal of bioenergetics and biomembranes 20111201 6
Amyotrophic lateral sclerosis (ALS) is the third most common human adult-onset neurodegenerative disease. Some forms of ALS are inherited, and disease-causing genes have been identified. Nevertheless, the mechanisms of neurodegeneration in ALS are unresolved. Genetic, biochemical, and morphological analyses of human ALS as well as cell and animal models of ALS reveal that mitochondria could have roles in this neurodegeneration. The varied functions and properties of mitochondria might render sub ...[more]
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2024-05-20 | GSE244021 | GEO