The effect of rilonacept versus placebo on health-related quality of life in patients with poorly controlled familial Mediterranean fever.

ABSTRACT:

Objective

To examine the effect of rilonacept on the health-related quality of life (HRQoL) in patients with poorly controlled familial Mediterranean fever (FMF).

Methods

As part of a randomized, double-blinded trial comparing rilonacept and placebo for the treatment of FMF, patients/parents completed the modified Child Health Questionnaire (CHQ) at baseline, and at the start and end of each of 4 treatment courses, 2 each with rilonacept and placebo.

Results

Fourteen subjects were randomized; mean age was 24.4 ± 11.8 years. At baseline the physical HRQoL score was significantly less (24.2 ± 49.5) but the psychosocial score was similar to the population norm (49.5 ± 10.0). There were significant improvements in most HRQoL concepts after rilonacept but not placebo. Sign

SUBMITTER: Hashkes PJ 

PROVIDER: S-EPMC4131422 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature