Expression profiling of genes modulated by minocycline in a rat model of neuropathic pain.

ABSTRACT:

Background

The molecular mechanisms underlying neuropathic pain are constantly being studied to create new opportunities to prevent or alleviate neuropathic pain. The aim of our study was to determine the gene expression changes induced by sciatic nerve chronic constriction injury (CCI) that are modulated by minocycline, which can effectively diminish neuropathic pain in animal studies. The genes associated with minocycline efficacy in neuropathic pain should provide insight into the etiology of neuropathic pain and identify novel therapeutic targets.

Results

We screened the ipsilateral dorsal part of the lumbar spinal cord of the rat CCI model for differentially expressed genes. Out of 22,500 studied transcripts, the abundance levels of 93 transcripts were altered following

SUBMITTER: Rojewska E 

PROVIDER: S-EPMC4131481 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature