Diagnostic and prognostic value of soluble syndecan-1 in pleural malignancies.

ABSTRACT:

Background

The distinction between malignant and benign pleural effusions is a diagnostic challenge today and measuring soluble biomarkers could add to the diagnostic accuracy. Syndecan-1 is a proteoglycan involved in various cellular functions and is cleaved from the cell surface in a regulated manner. The shed fragment, which can be recovered in effusion supernatant and in serum, retains its binding capacities, but often with different functions and signalling properties than the cell-bound form.

Aim

This study aimed to investigate the diagnostic and prognostic value of soluble syndecan-1 in pleural effusions and sera from patients with pleural malignancies.

Study design

Using two cohorts of patients, we assessed the diagnostic and prognostic value of soluble syndec

SUBMITTER: Mundt F 

PROVIDER: S-EPMC4131558 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature