Cytosporinols A-C, new caryophyllene sesquiterpenoids from Cytospora sp.

ABSTRACT: Three new caryophyllene sesquiterpenoids, cytosporinols A-C (1–3), have been isolated from solid cultures of Cytospora sp. The structures of 1–3 were elucidated primarily by NMR spectroscopy, and 3 was further confirmed by X-ray crystallography. The absolute configurations of the C-11 secondary alcohol in 1 and the 6,8-diol moiety in 3 were deduced using the modified Mosher and Snatzke’s method, respectively. Compounds 2 and 3 showed moderate cytotoxicity against HeLa cells.

Electronic Supplementary Material

Supplementary material is available for this article at 10.1007/s13659-012-0018-z and is accessible for authorized users.

SUBMITTER: Li Y 

PROVIDER: S-EPMC4131587 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature