Predicting hepatic steatosis in a racially and ethnically diverse cohort of adolescent girls.

ABSTRACT:

Objective

To develop a risk assessment model for early detection of hepatic steatosis using common anthropometric and metabolic markers.

Study design

This was a cross-sectional study of 134 adolescent and young adult females, age 11-22 years (mean 13.3±2 years) from a middle school and clinics in Madison, Wisconsin. The ethnic distribution was 27% Hispanic and 73% non-Hispanic; the racial distribution was 64% Caucasian, 31% African-American, and 5% Asian, Fasting glucose, fasting insulin, alanine aminotransferase (ALT), body mass index (BMI), waist circumference (WC), and other metabolic markers were assessed. Hepatic fat was quantified using magnetic resonance imaging proton density fat fraction (MR-PDFF). Hepatic steatosis was defined as MR-PDFF>5.5%. Outcome measures were

SUBMITTER: Rehm JL 

PROVIDER: S-EPMC4131842 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature