Impact of early life adversity on reward processing in young adults: EEG-fMRI results from a prospective study over 25 years.

ABSTRACT: Several lines of evidence have implicated the mesolimbic dopamine reward pathway in altered brain function resulting from exposure to early adversity. The present study examined the impact of early life adversity on different stages of neuronal reward processing later in life and their association with a related behavioral phenotype, i.e. attention deficit/hyperactivity disorder (ADHD). 162 healthy young adults (mean age = 24.4 years; 58% female) from an epidemiological cohort study followed since birth participated in a simultaneous EEG-fMRI study using a monetary incentive delay task. Early life adversity according to an early family adversity index (EFA) and lifetime ADHD symptoms were assessed using standardized parent interviews conducted at the offspring's age of 3 months and between

SUBMITTER: Boecker R 

PROVIDER: S-EPMC4131910 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature