Holoprosencephaly: a guide to diagnosis and clinical management.

ABSTRACT:

Context

Holoprosencephaly affects 1 in 8,000 live births and is the most common structural anomaly of the developing forebrain, resulting in facial dysmorphism, neurologic impairment, and additional clinical sequelae. Given the increasing relative contribution of genetic diseases to perinatal morbidity and mortality in India, proper recognition and management of holoprosencephaly can improve care for a significant number of affected Indian children.

Evidence acquisition

We used the PubMed database (search terms: "holoprosencephaly," "HPE," "holoprosencephaly India") and cross-referenced articles regarding holoprosencephaly, using our research group's extensive experience as a guide for identifying seminal papers in the field.

Results

Holoprosencephaly is classified in

SUBMITTER: Raam MS 

PROVIDER: S-EPMC4131946 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature