NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound.

ABSTRACT: Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of (195)Pt and (15)N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

SUBMITTER: Wedlock LE 

PROVIDER: S-EPMC4132055 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature