Vaccine-mediated immune responses to experimental pulmonary Cryptococcus gattii infection in mice.

ABSTRACT: Cryptococcus gattii is a fungal pathogen that can cause life-threatening respiratory and disseminated infections in immune-competent and immune-suppressed individuals. Currently, there are no standardized vaccines against cryptococcosis in humans, underlying an urgent need for effective therapies and/or vaccines. In this study, we evaluated the efficacy of intranasal immunization with C. gattii cell wall associated (CW) and/or cytoplasmic (CP) protein preparations to induce protection against experimental pulmonary C. gattii infection in mice. BALB/c mice immunized with C. gattii CW and/or CP protein preparations exhibited a significant reduction in pulmonary fungal burden and prolonged survival following pulmonary challenge with C. gattii. Protection was associated with significantly incr

SUBMITTER: Chaturvedi AK 

PROVIDER: S-EPMC4132117 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature