Interplay of interlocus gene conversion and crossover in segmental duplications under a neutral scenario.

ABSTRACT: Interlocus gene conversion is a major evolutionary force that drives the concerted evolution of duplicated genomic regions. Theoretical models successfully have addressed the effects of interlocus gene conversion and the importance of crossover in the evolutionary fate of gene families and duplications but have not considered complex recombination scenarios, such as the presence of hotspots. To study the interplay between interlocus gene conversion and crossover, we have developed a forward-time simulator that allows the exploration of a wide range of interlocus gene conversion rates under different crossover models. Using it, we have analyzed patterns of nucleotide variation and linkage disequilibrium within and between duplicate regions, focusing on a neutral scenario with constant popul

SUBMITTER: Hartasanchez DA 

PROVIDER: S-EPMC4132178 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature