Phase I/II randomized trial of aerobic exercise in Parkinson disease in a community setting.

ABSTRACT:

Objectives

To (1) investigate effects of aerobic walking on motor function, cognition, and quality of life in Parkinson disease (PD), and (2) compare safety, tolerability, and fitness benefits of different forms of exercise intervention: continuous/moderate intensity vs interval/alternating between low and vigorous intensity, and individual/neighborhood vs group/facility setting.

Methods

Initial design was a 6-month, 2 × 2 randomized trial of different exercise regimens in independently ambulatory patients with PD. All arms were required to exercise 3 times per week, 45 minutes per session.

Results

Randomization to group/facility setting was not feasible because of logistical factors. Over the first 2 years, we randomized 43 participants to continuous or interval trai

SUBMITTER: Uc EY 

PROVIDER: S-EPMC4132568 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature