The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA.

ABSTRACT: Histone biogenesis is tightly controlled at multiple steps to maintain the balance between the amounts of DNA and histone protein during the cell cycle. In particular, translation and degradation of replication-dependent histone mRNAs are coordinately regulated. However, the underlying molecular mechanisms remain elusive. Here, we investigate remodeling of stem-loop binding protein (SLBP)-containing histone mRNPs occurring during the switch from the actively translating mode to the degradation mode. The interaction between a CBP80/20-dependent translation initiation factor (CTIF) and SLBP, which is important for efficient histone mRNA translation, is disrupted upon the inhibition of DNA replication or at the end of S phase. This disruption is mediated by competition between CTIF and UPF1 f

SUBMITTER: Choe J 

PROVIDER: S-EPMC4132728 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature