Elevated serum pesticide levels and risk for Alzheimer disease.

ABSTRACT:

Importance

The causes of late-onset Alzheimer disease (AD) are not yet understood but likely include a combination of genetic, environmental, and lifestyle factors. Limited epidemiological studies suggest that occupational pesticide exposures are associated with AD. Previously, we reported that serum levels of dichlorodiphenyldichloroethylene (DDE), the metabolite of the pesticide dichlorodiphenyltrichloroethane (DDT), were elevated in a small number of patients with AD (n=20).

Objective

To evaluate the association between serum levels of DDE and AD and whether the apolipoprotein E (APOE) genotype modifies the association.

Design, setting, and participants

A case-control study consisting of existing samples from patients with AD and control participants from the Emory

SUBMITTER: Richardson JR 

PROVIDER: S-EPMC4132934 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature