Unveiling time in dose-response models to infer host susceptibility to pathogens.

ABSTRACT: The biological effects of interventions to control infectious diseases typically depend on the intensity of pathogen challenge. As much as the levels of natural pathogen circulation vary over time and geographical location, the development of invariant efficacy measures is of major importance, even if only indirectly inferrable. Here a method is introduced to assess host susceptibility to pathogens, and applied to a detailed dataset generated by challenging groups of insect hosts (Drosophila melanogaster) with a range of pathogen (Drosophila C Virus) doses and recording survival over time. The experiment was replicated for flies carrying the Wolbachia symbiont, which is known to reduce host susceptibility to viral infections. The entire dataset is fitted by a novel quantitative framework t

SUBMITTER: Pessoa D 

PROVIDER: S-EPMC4133050 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature