Transcriptome sequencing from diverse human populations reveals differentiated regulatory architecture.

ABSTRACT: Large-scale sequencing efforts have documented extensive genetic variation within the human genome. However, our understanding of the origins, global distribution, and functional consequences of this variation is far from complete. While regulatory variation influencing gene expression has been studied within a handful of populations, the breadth of transcriptome differences across diverse human populations has not been systematically analyzed. To better understand the spectrum of gene expression variation, alternative splicing, and the population genetics of regulatory variation in humans, we have sequenced the genomes, exomes, and transcriptomes of EBV transformed lymphoblastoid cell lines derived from 45 individuals in the Human Genome Diversity Panel (HGDP). The populations sampled spa

SUBMITTER: Martin AR 

PROVIDER: S-EPMC4133153 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature