Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma.

ABSTRACT:

Objective

Blunt trauma and traumatic spinal cord injury induce systemic inflammation that contributes to morbidity. Dysregulated neural control of systemic inflammation postinjury is likely exaggerated in patients with traumatic spinal cord injury. We used in silico methods to discern dynamic inflammatory networks that could distinguish systemic inflammation in traumatic spinal cord injury from blunt trauma.

Design

Retrospective study.

Settings

Tertiary care institution.

Patients

Twenty-one severely injured thoracocervical traumatic spinal cord injury patients and matched 21 severely injured blunt trauma patients without spinal cord injury.

Intervention

None.

Measurements and main results

Serial blood samples were obtained from days 1 to 14 postin

SUBMITTER: Zaaqoq AM 

PROVIDER: S-EPMC4133186 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature