The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies between rodent models and humans.

ABSTRACT: PGC-1α regulates critical processes in muscle physiology, including mitochondrial biogenesis, lipid metabolism and angiogenesis. Furthermore, PGC-1α was suggested as an important regulator of fiber type determination. However, whether a muscle fiber type-specific PGC-1α content exists, whether PGC-1α content relates to basal levels of mitochondrial content, and whether such relationships are preserved between humans and classically used rodent models are all questions that have been either poorly addressed or never investigated. To address these issues, we investigated the fiber type-specific content of PGC-1α and its relationship to basal mitochondrial content in mouse, rat and human muscles using in situ immunolabeling and histochemical methods on muscle serial cross-sections. Whereas ty

SUBMITTER: Gouspillou G 

PROVIDER: S-EPMC4133187 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature