Cholesterol selectively regulates IL-5 induced mitogen activated protein kinase signaling in human eosinophils.

ABSTRACT: Eosinophils function contributes to human allergic and autoimmune diseases, many of which currently lack curative treatment. Development of more effective treatments for eosinophil-related diseases requires expanded understanding of eosinophil signaling and biology. Cell signaling requires integration of extracellular signals with intracellular responses, and is organized in part by cholesterol rich membrane microdomains (CRMMs), commonly referred to as lipid rafts. Formation of these organizational membrane domains is in turn dependent upon the amount of available cholesterol, which can fluctuate widely with a variety of disease states. We tested the hypothesis that manipulating membrane cholesterol content in primary human peripheral blood eosinophils (PBEos) would selectively alter sign

SUBMITTER: Burnham ME 

PROVIDER: S-EPMC4133209 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature