Lower intensified target LDL-c level of statin therapy results in a higher risk of incident diabetes: a meta-analysis.

ABSTRACT:

Background

A recent meta-analysis has reported that intensive-dose statin drug increases the risk of incident diabetes. However, doubling of the statin dose generates only a further 6% decrease in low-density lipoprotein cholesterol (LDL-c) on average. This study aimed to determine whether statin therapy with lower intensive-target LDL-c level contributes to higher risk of new-onset diabetes.

Methods

Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched for randomized controlled endpoint trials of statins conducted from 1966 to 2012. We included trials with more than 1000 participants who were followed up for at least 2 years. The included trials were stratified by the target LDL-c level. I2 statistic was used to measure heterogeneity between

SUBMITTER: Cai R 

PROVIDER: S-EPMC4133238 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature