Bone morphogenetic protein 6 polymorphisms are associated with radiographic progression in ankylosing spondylitis.

ABSTRACT:

Background and object

Nearly 25 genetic loci associated with susceptibility to ankylosing spondylitis (AS) have been identified by several large studies. However, there have been limited studies to identify the genes associated with radiographic severity of the disease. Thus we investigated which genes involved in bone formation pathways might be associated with radiographic severity in AS.

Methods

A total of 417 Korean AS patients were classified into two groups based on the radiographic severity as defined by the modified Stoke' Ankylosing Spondylitis Spinal Score (mSASSS) system. Severe AS was defined by the presence of syndesmophytes and/or fusion in the lumbar or cervical spine (n = 195). Mild AS was defined by the absence of any syndesmophyte or fusion (n = 170). A tot

SUBMITTER: Joo YB 

PROVIDER: S-EPMC4133264 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature