Association of recent exposure to ambient metals on fractional exhaled nitric oxide in 9-11 year old inner-city children.

ABSTRACT: Exposure to ambient metals in urban environments has been associated with wheeze, and emergency room visits and hospitalizations due to respiratory illness. However, the effect of ambient metals exposure on airway inflammation, and how these associations may be modified by seroatopy, has not been determined. Fractional exhaled nitric oxide (FENO) is a reliable proxy marker of airway inflammation. We hypothesized that recent ambient concentrations of Ni, V, Zn and Fe would be associated differentially with proximal and distal fractions of exhaled NO, and that these associations would be modified by seroatopy. As part of the Columbia Center for Children's Environmental Health (CCCEH) birth cohort study, 9-11 year old children (n=192) were evaluated. Ambient measures of Ni, V, Zn and Fe were

SUBMITTER: Rosa MJ 

PROVIDER: S-EPMC4133318 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature