Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages.

ABSTRACT:

Background

Inflammation triggered by infection or injury is tightly controlled by glucocorticoid hormones which signal via a dedicated transcription factor, the Glucocorticoid Receptor (GR), to regulate hundreds of genes. However, the hierarchy of transcriptional responses to GR activation and the molecular basis of their oftentimes non-linear dynamics are not understood.

Results

We investigated early glucocorticoid-driven transcriptional events in macrophages, a cell type highly responsive to both pro- and anti-inflammatory stimuli. Using whole transcriptome analyses in resting and acutely lipopolysaccharide (LPS)-stimulated macrophages, we show that early GR target genes form dense networks with the majority of control nodes represented by transcription factors. The expres

SUBMITTER: Chinenov Y 

PROVIDER: S-EPMC4133603 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature