Discovery of co-occurring driver pathways in cancer.

ABSTRACT:

Background

It has been widely realized that pathways rather than individual genes govern the course of carcinogenesis. Therefore, discovering driver pathways is becoming an important step to understand the molecular mechanisms underlying cancer and design efficient treatments for cancer patients. Previous studies have focused mainly on observation of the alterations in cancer genomes at the individual gene or single pathway level. However, a great deal of evidence has indicated that multiple pathways often function cooperatively in carcinogenesis and other key biological processes.

Results

In this study, an exact mathematical programming method was proposed to de novo identify co-occurring mutated driver pathways (CoMDP) in carcinogenesis without any prior information beyond

SUBMITTER: Zhang J 

PROVIDER: S-EPMC4133618 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature