Elevated C-reactive protein associated with late- and very-late-onset schizophrenia in the general population: a prospective study.

ABSTRACT:

Background

Individuals with autoimmune diseases and severe infections have persistent or acutely elevated inflammatory biomarkers and increased risk of schizophrenia. We tested the hypothesis that baseline elevated plasma levels of the inflammatory biomarker, C-reactive protein (CRP), associate with increased risk of late- and very-late-onset schizophrenia in the general population, and if such an association possibly is causal.

Method

We analyzed data from 78 810 men and women, aged 20-100 years, from 2 large population studies. Endpoints were hospitalization with schizophrenia and schizophrenia and schizophrenia-like psychosis combined. We performed prospective and cross-sectional analyses adjusted for potential confounders with up to 20 years of follow-up. Furthermore, we

SUBMITTER: Wium-Andersen MK 

PROVIDER: S-EPMC4133657 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature