Elevated antisaccade error rate as an intermediate phenotype for psychosis across diagnostic categories.

ABSTRACT:

Background

Elevated antisaccade error rate, reflecting problems with inhibitory behavioral control, is a promising intermediate phenotype for schizophrenia. Here, we consider whether it marks liability across psychotic disorders via common or different neurophysiological mechanisms and whether it represents a neurocognitive risk indicator apart from the generalized cognitive deficit.

Methods

Schizophrenia (n = 267), schizoaffective (n = 150), and psychotic bipolar (n = 202) probands, their first-degree relatives (ns = 304, 193, 242, respectively), and healthy controls (n = 244), participating in the Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium, performed antisaccade and prosaccade tasks and completed a neuropsychological battery.

Results

Antisac

SUBMITTER: Reilly JL 

PROVIDER: S-EPMC4133662 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature