Accelerated brain aging in schizophrenia and beyond: a neuroanatomical marker of psychiatric disorders.

ABSTRACT: Structural brain abnormalities are central to schizophrenia (SZ), but it remains unknown whether they are linked to dysmaturational processes crossing diagnostic boundaries, aggravating across disease stages, and driving the neurodiagnostic signature of the illness. Therefore, we investigated whether patients with SZ (N = 141), major depression (MD; N = 104), borderline personality disorder (BPD; N = 57), and individuals in at-risk mental states for psychosis (ARMS; N = 89) deviated from the trajectory of normal brain maturation. This deviation was measured as difference between chronological and the neuroanatomical age (brain age gap estimation [BrainAGE]). Neuroanatomical age was determined by a machine learning system trained to individually estimate age from the structural magnetic res

SUBMITTER: Koutsouleris N 

PROVIDER: S-EPMC4133663 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature