Clonidine normalizes levels of P50 gating in patients with schizophrenia on stable medication.

ABSTRACT:

Background

Sensory gating deficits are among the core features of schizophrenia. Recently, we reported significantly increased sensorimotor gating following additional administration of single dosages of clonidine to the treatment of stably medicated patients with schizophrenia who, in spite of their medication, showed gating deficits. In the current study, we investigated whether this result is generalizable to filtering of sensory information as a whole, by examining clonidine's effect on P50 suppression in the same group of patients.

Methods

In a double-blind, placebo-controlled, randomized yet balanced cross-over design, 20 male schizophrenia patients on stable medication were assessed in a psychophysiological test battery, including a sensory gating paradigm on 5 occasi

SUBMITTER: Oranje B 

PROVIDER: S-EPMC4133664 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature