Survival in men with nonmetastatic prostate cancer treated with hormone therapy: a quantitative systematic review.

ABSTRACT:

Purpose

We aimed to describe disease-free survival (DFS) and overall survival (OS) in men with localized or locally advanced prostate cancer receiving immediate hormone therapy as adjunct to radiation therapy, adjunct to radical prostatectomy, or stand-alone therapy.

Materials and methods

A systematic literature search of MEDLINE, EMBASE, CancerLit, the Cochrane Library, and Current Contents (from 1986 to September 2006) yielded 35 high-quality clinical trials (n = 11,105 patients) which formed the evidence base. Selected studies were required to address early hormone therapy in nonmetastatic prostate cancer only. Data on DFS and OS were extracted from individual trials, summarized statistically, and displayed in graphic form.

Results

Survival probabilities were extra

SUBMITTER: Antonarakis ES 

PROVIDER: S-EPMC4133788 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature