Egg-white-specific IgA and IgA2 antibodies in egg-allergic children: is there a role in tolerance induction?

ABSTRACT:

Background

Decreased serum food-specific IgA antibodies have been associated with allergic disease in cross-sectional, case-control studies. The purpose of this study was to prospectively compare egg-white-(EW)-specific IgA and IgA2 levels between egg-allergic children and children tolerating egg.

Methods

Seventeen egg-allergic children were followed prospectively. Total IgA, EW-specific IgA, and EW-specific IgA2 levels were measured in their sera with a sensitive ELISA. As negative controls were used children with no previous history of egg allergy. Egg-allergic children with or without concomitant milk allergy were evaluated as additional controls with measurement of casein-specific IgA.

Results

After 2.5 ± 0.9 yrs, nine out of the 17 allergic children became tolera

SUBMITTER: Konstantinou GN 

PROVIDER: S-EPMC4134474 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature