Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.

ABSTRACT:

Background

Over the past years, some members of the family of suppressor of cytokine signalling (SOCS) proteins have emerged as potential tumour suppressors. This study aimed at investigating the clinical significance of SOCS proteins in colorectal carcinoma (CRC).

Methods

We integrated publicly available microarray expression data on CRC in humans, analysed the expression pattern of SOCSs and assessed the predictive power of SOCS2 and SOCS6 for diagnostic purposes by generating receiver operating characteristic curves. Using laser microdissected patient material we assessed SOCS expression on RNA and protein levels as well as their methylation status in an independent CRC patient cohort. Finally, we investigated the prognostic value of SOCS2 and SOCS6.

Results

The me

SUBMITTER: Letellier E 

PROVIDER: S-EPMC4134506 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature