Highly selective fluorescence off-on probes for biothiols and imaging in live cells.

ABSTRACT: Three sulfonyl benzothiazole-based fluorescent probes (, , and ) for the detection of biothiols (cysteine, homocysteine, and glutathione) are developed based on thiol-mediated nucleophilic aromatic substitutions. The probes exhibited good selectivity and sensitivity toward biothiols over other analytes. The probes were successfully applied for visualizing endogenous thiols in living cells.

SUBMITTER: Zhang D 

PROVIDER: S-EPMC4134666 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature