Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors.

ABSTRACT:

Objectives

To evaluate the independent and joint effects of genetic factors and environmental variables on advanced forms of age-related macular degeneration (AMD), including geographic atrophy and choroidal neovascularization, and to develop a predictive model with genetic and environmental factors included.

Methods

Demographic information, including age at onset, smoking status, and body mass index, was collected for 1844 participants. Genotypes were evaluated for 8 variants in 5 genes related to AMD. Unconditional logistic regression analyses were performed to generate a risk predictive model.

Results

All genetic variants showed a strong association with AMD. Multivariate odds ratios were 3.52 (95% confidence interval, 2.08-5.94) for complement factor H, CFH rs1061

SUBMITTER: Chen Y 

PROVIDER: S-EPMC4134685 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature