Capillary-wall collagen as a biophysical marker of nanotherapeutic permeability into the tumor microenvironment.

ABSTRACT: The capillary wall is the chief barrier to tissue entry of therapeutic nanoparticles, thereby dictating their efficacy. Collagen fibers are an important component of capillary walls, affecting leakiness in healthy or tumor vasculature. Using a computational model along with in vivo systems, we compared how collagen structure affects the diffusion flux of a 1-nm chemotherapeutic molecule [doxorubicin (DOX)] and an 80-nm chemotherapy-loaded pegylated liposome (DOX-PLD) in tumor vasculature. We found a direct correlation between the collagen content around a tumor vessel to the permeability of that vessel permeability to DOX-PLD, indicating that collagen content may offer a biophysical marker of extravasation potential of liposomal drug formulations. Our results also suggested that while phar

SUBMITTER: Yokoi K 

PROVIDER: S-EPMC4134692 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature