SLC6 family transporter SNF-10 is required for protease-mediated activation of sperm motility in C. elegans.

ABSTRACT: Motility of sperm is crucial for their directed migration to the egg. The acquisition and modulation of motility are regulated to ensure that sperm move when and where needed, thereby promoting reproductive success. One specific example of this phenomenon occurs during differentiation of the ameboid sperm of Caenorhabditis elegans as they activate from a round spermatid to a mature, crawling spermatozoon. Sperm activation is regulated by redundant pathways to occur at a specific time and place for each sex. Here, we report the identification of the solute carrier 6 (SLC6) transporter protein SNF-10 as a key regulator of C. elegans sperm activation in response to male protease activation signals. We find that SNF-10 is present in sperm and is required for activation by the male but not by t

SUBMITTER: Fenker KE 

PROVIDER: S-EPMC4134694 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature