Low glomerular filtration rate, recurrent stroke risk, and effect of renin-angiotensin system modulation.

ABSTRACT:

Background and purpose

To investigate the association of low estimated glomerular filtration rate (eGFR) <60 mL/min with recurrent stroke risk and to evaluate whether add-on renin-angiotensin system modulator therapy is associated with lower recurrent stroke risk in patients with low eGFR.

Methods

We analyzed the database of a multicenter trial involving 18,666 patients with recent ischemic stroke followed for 2.5 years. Primary outcome was time to first recurrent stroke. Independent associations of low eGFR with outcome in the entire cohort and add-on telmisartan treatment with outcome among those with low eGFR were evaluated.

Results

Low eGFR was observed in 3630 (20.1%) patients. Patients with low eGFR were older, more likely women, with a known history of hyperten

SUBMITTER: Ovbiagele B 

PROVIDER: S-EPMC4134879 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature