Plasma total homocysteine and carotid intima-media thickness in type 1 diabetes: a prospective study.

ABSTRACT:

Objective

Plasma total homocysteine (tHcy) has been positively associated with carotid intima-media thickness (IMT) in non-diabetic populations and in a few cross-sectional studies of diabetic patients. We investigated cross-sectional and prospective associations of a single measure of tHcy with common and internal carotid IMT over a 6-year period in type 1 diabetes.

Research design and methods

tHcy levels were measured once, in plasma obtained in 1997-1999 from patients (n = 599) in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, the observational follow-up of the Diabetes Control and Complications Trial (DCCT). Common and internal carotid IMT were determined twice, in EDIC "Year 6" (1998-2000) and "Year 12" (2004-2006), using B-mode ultra-sonogra

SUBMITTER: Basu A 

PROVIDER: S-EPMC4134979 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature