Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer.

ABSTRACT:

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FAM83B (family with sequence similarity 83, member B) was recently identified as a novel oncogene involved in activating CRAF/MAPK signaling and driving epithelial cell transformation. FAM83B is one of eight members of a protein family (FAM83) characterized by a highly conserved domain of unknown function (DUF1669), which is necessary and sufficient to drive transformation. Here, it is demonstrated that additional FAM83 members also exhibit oncogenic properties and have significantly elevated levels of expression in multiple human tumor types using a TissueScan Cancer Survey Panel PCR array and database mining. Furthermore, modeling the observed tumor expression of FAM83A, FAM83C, FAM83D, or FAM83E promoted human mammary epithelial cell (HMEC) transformation, which corre

SUBMITTER: Cipriano R 

PROVIDER: S-EPMC4135001 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature