Identification of glutamate ABC-Transporter component in Clostridium perfringens as a putative drug target.

ABSTRACT: Clostridium perfringens is an anaerobic pathogen known to cause vast number of diseases in mammals and birds. Various toxins and hydrolysing enzymes released by the organism are responsible for the necrosis of soft tissues. Due to serious safety issues associated with current vaccines against C. perfringens, there is a need for new drug or vaccine targets. C. perfringens is extremely dependent on its host for nutrition which can be targeted for vaccine development or drug design. Therefore, it is of interest to identify the unique transport systems used by C. perfringens involved in uptake of essential amino acids that are synthesized by the host, so that therapeutic agents can be designed to target the specific transport systems. Use of bioinformatics tools resulted in the identification

SUBMITTER: Bhatia B 

PROVIDER: S-EPMC4135286 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature