Identification of regulatory elements that control expression of the tbpBA operon in Neisseria gonorrhoeae.

ABSTRACT: Iron is an essential nutrient for survival and establishment of infection by Neisseria gonorrhoeae. The neisserial transferrin binding proteins (Tbps) comprise a bipartite system for iron acquisition from human transferrin. TbpA is the TonB-dependent transporter that accomplishes iron internalization. TbpB is a surface-exposed lipoprotein that makes the iron uptake process more efficient. Previous studies have shown that the genes encoding these proteins are arranged in a bicistronic operon, with the tbpB gene located upstream of tbpA and separated from it by an inverted repeat. The operon is under the control of the ferric uptake regulator (Fur); however, promoter elements necessary for regulated expression of the genes have not been experimentally defined. In this study, putative regulat

SUBMITTER: Velez Acevedo RN 

PROVIDER: S-EPMC4135677 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature