Evaluation of the contributions of individual viral genes to newcastle disease virus virulence and pathogenesis.

ABSTRACT:

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Naturally occurring Newcastle disease virus (NDV) strains vary greatly in virulence. The presence of multibasic residues at the proteolytic cleavage site of the fusion (F) protein has been shown to be a primary determinant differentiating virulent versus avirulent strains. However, there is wide variation in virulence among virulent strains. There also are examples of incongruity between cleavage site sequence and virulence. These observations suggest that additional viral factors contribute to virulence. In this study, we evaluated the contribution of each viral gene to virulence individually and in different combinations by exchanging genes between velogenic (highly virulent) strain GB Texas (GBT) and mesogenic (moderately virulent) strain Beaudette C (BC). These two s

SUBMITTER: Paldurai A 

PROVIDER: S-EPMC4135945 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature