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Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.

ABSTRACT: Genome sequencing of carbapenem-resistant Klebsiella pneumoniae isolates from regional U.S. hospitals was used to characterize strain diversity and the bla(KPC) genetic context. A phylogeny based on core single-nucleotide variants (SNVs) supports a division of sequence type 258 (ST258) into two distinct groups. The primary differences between the groups are in the capsular polysaccharide locus (cps) and their plasmid contents. A strict association between clade and KPC variant was found. The bla(KPC) gene was found on variants of two plasmid backbones. This study indicates that highly similar K. pneumoniae subpopulations coexist within the same hospitals over time.

SUBMITTER: Wright MS 

PROVIDER: S-EPMC4136011 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.

Wright Meredith S MS   Perez Federico F   Brinkac Lauren L   Jacobs Michael R MR   Kaye Keith K   Cober Eric E   van Duin David D   Marshall Steven H SH   Hujer Andrea M AM   Rudin Susan D SD   Hujer Kristine M KM   Bonomo Robert A RA   Adams Mark D MD  

Antimicrobial agents and chemotherapy 20140609 8

Genome sequencing of carbapenem-resistant Klebsiella pneumoniae isolates from regional U.S. hospitals was used to characterize strain diversity and the bla(KPC) genetic context. A phylogeny based on core single-nucleotide variants (SNVs) supports a division of sequence type 258 (ST258) into two distinct groups. The primary differences between the groups are in the capsular polysaccharide locus (cps) and their plasmid contents. A strict association between clade and KPC variant was found. The bla  ...[more]

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